Understanding Clinical Trials

Understanding Clinical Trials

What is a primary / secondary endpoint?

Clinical trial endpoints can be classified as primary or secondary. The primary endpoint is the most important outcome and is used to assess the primary objective of a trial.
  • Primary endpoints measure outcomes that will answer the primary or most important question being asked by a trial, such as whether a new treatment is better at preventing disease-related death than the standard therapy33.
  • Secondary endpoints answer other relevant questions about the same study; for example, whether there is also a reduction in disease measures other than death,33 or outcomes rated by patients such as quality of life34.

 

 

 

 

33. OBSSR. Clinical Trials - Endpoints. Available at: http://www.esourceresearch.org/eSourceBook/ClinicalTrials/4Endpoints/tabid/200/Default.aspx. Accessed: 25 Apr 2019.

34. Kilickap S, et al. JBUON 2018;23(Suppl 1):S1-S6.